New: A brand-new, unused, unopened, undamaged item in its original packaging (where packaging is ... New: A brand-new, unused, unopened, undamaged item in its original packaging (where packaging is applicable). Packaging should be the same as what is found in a retail store, unless the item is handmade or was packaged by the manufacturer in non-retail packaging, such as an unprinted box or plastic bag. See the seller's listing for full details.
Y-mAbs is a commercial-stage clinical biopharmaceutical company focused on the development and commercialization of novel, antibody-based therapeutic products for the treatment of cancer. We have a broad and advanced product pipeline, including pivotal-stage product candidates against a range of targets.
Our mission is to become the world leader in developing better and safer antibody-based oncology products addressing clear unmet pediatric and adult medical needs. With the right partnerships and collaborations, we envision changing the course of cancer care and its outcomes.
Neuroblastoma: A rare pediatric cancer of the nervous system that usually starts on the glands above the kidney and can spread to the abdomen, spine, chest, neck, or pelvis.
Central Nervous System (CNS)/Leptomeningeal Metastases (LM): This condition occurs when cancer spreads to the membranes lining the brain and spinal cord. This can result from many types of cancer, including neuroblastoma.
Osteosarcoma: A cancer that starts in the bones and often develops around the knee or the upper arm.
Diffuse Intrinsic Pontine Glioma (DIPG): A highly aggressive and difficult-to-treat tumor found at the base of the brain.
Medulloblastoma: A type of cancer that starts in the lowest back part of the brain (the cerebellum). Although rare, it is the most common cancerous brain tumor found in children.
Desmoplastic Small Round Cell Tumor (DSRCT): A rare tumor that is usually located in the abdomen.
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Our Research & Development
What is antibody immunotherapy and how can it help?
Antibody immunotherapy is a type of treatment that’s designed to target specific antigens (molecules that stimulate an immune response) in the body and neutralize them. In early and ongoing clinical trials, the antibodies developed by Y-mAbs have shown results that garner continued evaluation.
Y-mAbs was founded by Thomas Gad, President and Head of Business Development and Strategy, who is also the father of a high-risk neuroblastoma survivor.
After years of searching for an effective option for neuroblastoma, Gad's daughter received treatment from Memorial Sloan Kettering Cancer Center (MSKCC). Since then, Gad has envisioned helping other patients and families get access to the same products.
Y-mAbs may someday help patients fight cancer with their advanced pipeline of antibody immunotherapies, which are currently being investigated in ongoing clinical trials.
For Medical Professionals
Pediatric cancer has long been a challenge for the medical profession. With years of growing knowledge and insights, treatment advancements are being made through research.
Y-mAbs is working to develop targeted approaches to treating rare and challenging pediatric cancers with the hope of extending survival and helping with safety concerns.
For Investors
Y-mAbs Therapeutics, Inc. (Y-mAbs), is a state-of-the-art, late-stage clinical, global biopharmaceutical company that is focused on the research and development of innovative antibody-based products under investigation using a range of cutting-edge technologies, licensed from one of the largest and most prestigious cancer-care establishments in the world—MSKCC.
With its robust pipeline, Y-mAbs is committed to becoming a world leader in creating pediatric-based oncology treatments.
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Please click for full Prescribing Information and Patient Information for DANYELZA including BOXED WARNING on serious infusion-related reactions and neurotoxicity.
INDICATION
DANYELZA is indicated, in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF), for the treatment of pediatric patients 1 year of age and older and adult patients with relapsed or refractory high-risk neuroblastoma in the bone or bone marrow who have demonstrated a partiaI response, minor response, or stable disease to prior therapy.
This indication is approved under accelerated approval based on overalI response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial(s).
SELECTED IMPORTANT SAFETY INFORMATION
WARNING: SERIOUS INFUSION-RELATED REACTIONS and NEUROTOXICITY
Serious Infusion-Related Reactions
DANYELZA can cause serious infusion reactions, including cardiac arrest, anaphylaxis, hypotension, bronchospasm, and stridor. Infusion reactions of any Grade occurred in 94-100% of patients. Severe infusion reactions occurred in 32-68% and serious infusion reactions occurred in 4-18% of patients in DANYELZA clinical studies.
Premedicate prior to each DANYELZA infusion as recommended and monitor patients for at least 2 hours following completion of each infusion. Reduce the rate, interrupt infusion, or permanently discontinue DANYELZA based on severity.
Neurotoxicity
DANYELZA can cause severe neurotoxicity, including severe neuropathic pain,transverse myelitis and reversible posterior leukoencephalopathy syndrome (RPLS). Pain of any Grade occurred in 94-100% of patients in DANYELZA clinical studies.
Premedicate to treat neuropathic pain as recommended. Permanently discontinue DANYELZA based on the adverse reaction and severity.
